A non-ionic water-soluble pentaphyrin derivative. Synthesis and cytotoxicity Original Research Article

The synthesis of the water soluble tetrahydroxypentaphyrin derivative, 1, is described. This species, which forms complexes with both small neutral molecules and uranyl cation, has been studied as a possible cytotoxic agent. Cytotoxic studies performed with the human T lymphoma cell line (JURKAT) revealed that pentaphyrin 1 exhibits toxicity at μM concentrations comparable with other water soluble, porphyrin-type systems such as the pyridinium metalloporphyrins.