Author/Authors :
Duvvuri Subrahmanyam، نويسنده , , V.M. Sarma، نويسنده , , A. Venkateswarlu، نويسنده , , T.V.R.S. Sastry، نويسنده , , Archana P. Kulakarni، نويسنده , , D. Srinivasa Rao، نويسنده , , K.V.S.R. Krishna Reddy، نويسنده ,
Abstract :
A number of 5-aminosubstituted 20(S)-camptothecin analogues were prepared via semi-synthesis starting from 20(S)-camptothecin and 9-methoxy 20(S)-camptothecin. In vitro anti-cancer activity of these analogues was determined using 60 human tumor cell line assay. Although water solubility of most of these compounds was improved compared to 20(S)-camptothecin, their anti-cancer activity was considerably diminished. However, only smaller substituents such as methylamine or hydroxylamine as present in and , respectively, showed good activity with improved water solubility.
