Author/Authors :
Eun Joo Roh، نويسنده , , Choong Eui Song، نويسنده , , Deukjoon Kim، نويسنده , , Hyun-Ock Pae، نويسنده , , Hun-Taeg Chung، نويسنده , , Kwan Sun Lee، نويسنده , , Ki-byung Chai، نويسنده , , Chong-Ock Lee، نويسنده , , Sang-Un Choi، نويسنده ,
Abstract :
The 3′-N-acyl-N-debenzoylpaclitaxel analogues were synthesized and evaluated on biological systems. Some of the analogues exhibited higher cytotoxicities (up to 20-fold) and stronger abilities to induce apoptosis than paclitaxel. In an in vivo experiment against ip implanted B16 melanoma, the most cytotoxic compound in vitro caused tumor growth inhibition more than paclitaxel.
Keywords :
Cytotoxicity , apoptosis , Structure–activity relationship , 3?-N-Acyl-N-debenzoylpaclitaxel analogues
