Author/Authors :
Simon J. Kitchin، نويسنده , , A.D. Borthwick، نويسنده , , A.C. Brodie، نويسنده , , P.C. Cherry، نويسنده , , A.J. Crame، نويسنده , , A.J. Pipe، نويسنده , , P.A. Procopiou، نويسنده , , M.A. Seaman، نويسنده , , J.P. Turnbull، نويسنده ,
Abstract :
A novel series of tetrahydrobenzodioxinopyrroles has been identified as potent and selective α2-adrenoceptor antagonists. Convergent syntheses have been developed that allowed the preparation of analogues and their enantiomers. A compound of particular interest is the 5-fluoro substituted analogue (fluparoxan).
