Author/Authors :
Paul Barraclough، نويسنده , , Mary L. Bolofo، نويسنده , , Heather Giles، نويسنده , , Janet Gillam، نويسنده , , C. John Harris، نويسنده , , Michael G. Kelly، نويسنده , , Paul Leff، نويسنده , , S.Alan McNeill، نويسنده , , Alan D. Robertson، نويسنده , , Ray J. Stepney، نويسنده , , Brendan J.R. Whittle، نويسنده ,
Abstract :
The rationale for investigating conformationally restricted analogues of BW245C as DP-receptor ligands and the syntheses of three such racemic bicyclic imidazolidinone analogues are described. Compounds 7 (BW587C), 8 (BW480C85), and 9 (BW572C85) were found to be potent inhibitors of human platelet aggregation and selective DP-receptor agonists in washed platelet and jugular vein isolated tissue assays.
