Title of article
Azabicyclic indole esters as potent 5-HT4 receptor antagonists Original Research Article
Author/Authors
Paul A. Wyman، نويسنده , , Laramie M. Gaster، نويسنده , , Frank D. King، نويسنده , , Jonathon M. Sutton، نويسنده , , Elizabeth S. Ellis، نويسنده , , Kay A. Wardle، نويسنده , , Timothy J. Young، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
7
From page
255
To page
261
Abstract
The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT4 receptor antagonists. Optimization of the most potent compound (19) by preparing the corresponding oxazino[3,2-a]indole ester afforded 34, which had a pIC50 of 9.5 in the guinea pig distal colon longitudinal muscle myenteric plexus preparation.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1996
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300637
Link To Document