Synthesis and inhibitory activity of glycosidase inhibitors, glycosylamino-oxazolines Original Research Article

In connection with structural modification of the trehalase inhibitor trehazolin (1), as a new-type of glycohydrolase inhibitor, some glycosylamino-oxazolines were designed and synthesized. Among three oxazolines β-galacto (3), β-gluco (5) and α-manno-types (6) obtained in stable form, the latter 6 has been shown to possess a moderate inhibitory activity against α-mannosidase.