Title of article
Synthesis of all possible regioisomers of scyllo-Inositol phosphate Original Research Article
Author/Authors
Sung-Kee Chung، نويسنده , , Yong-Uk Kwon، نويسنده , , Young Tae Chang، نويسنده , , Chulhee Lee and Kwanghoon Sohn، نويسنده , , Jung-Han Shin، نويسنده , , Kyu-Hwan Park، نويسنده , , Bong Jin Hong، نويسنده , , In-Hee Chung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
13
From page
2577
To page
2589
Abstract
scyllo-Inositol is the all equatorial stereoisomer of myo-inositol. All possible 12 regioisomers of scyllo-inositol phosphate were synthesized for the first time via a scyllo-inositol benzoate intermediate, which was derived from a myo-inositol derivative. The stereoinversion of myo-inositol into scyllo-inositol was accomplished by Mitsunobu reaction of the vicinal cis-diol. The requisite intermediates, scyllo-inositol benzoates were obtained by benzoyl migration or random benzoylation, and phosphorylated to give scyllo-IPn.
Keywords
Mitsunobu reaction , Inositol phosphates , benzoyl migration , scyllo-Inositol
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300664
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