Title of article
A new convenient transformation of erythromycin a into clarithromycin Original Research Article
Author/Authors
Pietro Allevi، نويسنده , , Alessandra Longo، نويسنده , , Mario Anastasia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2749
To page
2752
Abstract
Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2′,4′′-hydroxy groups, methylation of the resulting 2′,4′′-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.
Keywords
erythromycin A , methylation , Antibiotics , Clarithromycin , Antibacterials
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300688
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