Title of article :
Heterocondensed quinazolones: synthesis and protein-tyrosine kinase inhibitory activity of 3,4-dihydro-1H,6H-[1,4]oxazino-[3,4-b]quinazolin-6-one derivatives Original Research Article
Author/Authors :
L?szlo Orfi، نويسنده , , J?zsef K?k?si، نويسنده , , Gy?rgy Sz?sz، نويسنده , , Istv?n K?vesdi، نويسنده , , Marianna M?k، نويسنده , , Istv?n Tepl?n، نويسنده , , Gyorgy Keri، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Abstract :
1-Benzylidene (2–14) and 1-phenylhydrazono derivatives (15–29) of 3,4-dihydro-1H,6H-[1,4]oxazino[3,4-b]quinazolin-6-one (1) were obtained from the condensation reactions of 1 with a series of aromatic aldehydes and by direct diazonium coupling with aryl-diazonium chlorides. The substances were tested for their ability to inhibit the tyrosine kinase activity of SW-620 (human colon carcinoma) cells. Compounds 5, 10, 12, and 13 showed remarkable inhibitory activity.
Keywords :
4-b]quinazolin-6-ones , 1-phenylhydrazono-3 , 4-dihydro-1H , protein kinase inhibitory activity , 4-b]quinazolin-6-ones , SW-620 human colon carcinoma cells , Synthesis , 1-benzylidene-3 , 4-dihydro-1H
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
