Synthesis and evaluation as glycosidase inhibitors of 2,5-imino-d-glucitol and 1,5-imino-d-mannitol related derivatives Original Research Article

Selectively functionalized 2,5-imino-d-glucitol and 1,5-imino-d-mannitol derivatives were synthesized and tested as precursors of hydrolytically resistant pseudo-disaccharides. Among them N-acetyl-6-amino-6-deoxy-2,5-imino-d-glucitol () and N-acetyl-6-amino-6-deoxy-1,5-imino-d-mannitol () were found potent and specific inhibitors against β-d-glucosidase and α-l-fucosidase, respectively.