Synthesis of 4,17-diazasteroid inhibitors of human 5α-reductase Original Research Article

The synthesis of the 17-aza isomer of finasteride is described. With the side chain amide group of the compound existing in the Z configuration the structure is similar to one of the two favored conformations of finasteride. A series of 4.17-diazasteroids was assayed against the isoenzymes of human 5α-reductase.