Title of article :
Synthesis and structure–activity relationships of a new class of selective EP3 receptor agonist, 13,14-didehydro-16-phenoxy analogues of prostaglandin E1 Original Research Article
Author/Authors :
Youichi Shimazaki، نويسنده , , Kazuya Kameo، نويسنده , , Tohru Tanami، نويسنده , , Hideo Tanaka، نويسنده , , Naoya Ono، نويسنده , , Youichi Kiuchi، نويسنده , , Sentaro Okamoto، نويسنده , , Fumie Sato، نويسنده , , Atsushi Ichikawa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
A series of 13,14-didehydro-16-phenoxy analogues of prostaglandin E1 was synthesized and their agonistic activity on EP receptor subtypes was evaluated. 13,14-Didehydro-16-phenoxy-1-decarboxy analogues, and , display highly selective activity on the EP3 receptor subtype, thus, their utility as a selective anti-ulcer agent can be expected.
Keywords :
Prostaglandins , Agonists , Receptors , Substituent effects
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
