Title of article
Synthesis and biological activities of novel antiallergic agents with 5-lipoxygenase inhibiting action Original Research Article
Author/Authors
Hiroyuki Nakano، نويسنده , , Tsutomu Inoue، نويسنده , , Nobuhide Kawasaki، نويسنده , , Hideki Miyataka، نويسنده , , Hitoshi Matsumoto، نويسنده , , Takeo Taguchi، نويسنده , , Naoki Inagaki، نويسنده , , Hiroichi Nagai، نويسنده , , Toshio Satoh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
8
From page
373
To page
380
Abstract
Novel benzimidazole derivatives were synthesized and their pharmacological activities were examined. These compounds showed a good suppressive action on histamine release from rat peritoneal mast cells produced by antigen–antibody reaction, an antagonistic action on guinea pig ileum contraction caused by histamine, an inhibitory action on 5-lipoxygenase in rat basophilic leukemia-1 (RBL-1) cells, and a preventive action on NADPH dependent lipid peroxidation induced by Fe3+-ADP in rat liver microsomes. In addition, 1-[2-[2-(4-Hydroxy-2,3,5-trimethylphenoxy)ethoxy]-ethyl]-2-(4-methyl-1-homopiperazino)-1H-benzimidazole difumarate (BOM1006) exhibited a dose dependent suppressive action on 48 h homologous passive cutaneous anaphylaxis (PCA) reaction in rats orally administered the drug.
Keywords
Antioxidants , Allergies , Enzyme inhibitors , antagonists
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2000
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300849
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