Title of article
Synthesis and antitumor activity of selected 7-alkylidene substituted cephems Original Research Article
Author/Authors
G. Veinberg، نويسنده , , M. Vorona، نويسنده , , I. Shestakova، نويسنده , , I. Kanepe، نويسنده , , O. Zharkova، نويسنده , , R. Mezapuke، نويسنده , , I. Turovskis، نويسنده , , I. Kalvinsh، نويسنده , , E. Lukevics، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
8
From page
1033
To page
1040
Abstract
Selected 7-alkylidene substituted cephems were synthesized and subjected to antitumor assay. The effect of substituents was examined to establish structure–activity relationships. It was found that the intensive intracellular generation of nitric oxide induced by tert-butyl 7-alkylidene cephalosporanate sulfones could be also regarded as an additional cytotoxic factor taking place both in vitro and in vivo experiments.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2000
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301002
Link To Document