Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase Original Research Article
Author/Authors :
Dale L. Boger، نويسنده , , Marc A. Labroli، نويسنده , , Thomas H. Marsilje، نويسنده , , Qing Jin، نويسنده , , Michael P. Hedrick، نويسنده , , Stephen J. Baker، نويسنده , , Jae Hoon Shim، نويسنده , , Stephen J. Benkovic، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
12
From page :
1075
To page :
1086
Abstract :
The synthesis and evaluation of a series of conformationally restricted analogues of 10-formyl-tetrahydrofolate as potential inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) or aminoimidazole carboxamide transformylase (AICAR Tfase) are reported.
