Title of article
Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase Original Research Article
Author/Authors
Timothy F. Gallagher، نويسنده , , George L. Seibel، نويسنده , , Shouki Kassis، نويسنده , , Jeffrey T. Laydon، نويسنده , , Mary Jane Blumenthal، نويسنده , , John C. Lee، نويسنده , , Dennis Lee، نويسنده , , Jeffrey C. Boehm، نويسنده , , Susan M. Fier-Thompson، نويسنده , , Jeffrey W. Abt، نويسنده , , Margaret E. Soreson، نويسنده , , Juanita M. Smietana، نويسنده , , Ralph F. Hall، نويسنده , , Ravi S. Garigipati، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
16
From page
49
To page
64
Abstract
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential modes of binding to the enzyme are presented. For a subset of pyridinylimidazoles, binding is shown to correlate with inhibition of CSBP kinase activity, whereas no significant inhibition of PKA, PKCα and ERK kinase activity is observed.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301020
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