Title of article
Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase Original Research Article
Author/Authors
F. George Njoroge، نويسنده , , Ronald J. Doll، نويسنده , , Bancha Vibulbhan، نويسنده , , Carmen S. Alvarez، نويسنده , , W. Robert Bishop، نويسنده , , Joanne Petrin، نويسنده , , Paul Kirschmeier، نويسنده , , Nicholas I. Carruthers، نويسنده , , Jesse K. Wong، نويسنده , , Margaret M. Albanese، نويسنده , , John J. Piwinski، نويسنده , , Joseph Catino، نويسنده , , V. Girijavallabhan، نويسنده , , Ashit K. Ganguly، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
13
From page
101
To page
113
Abstract
A comprehensive structure-activity relationship (SAR) study of novel tricyclic amides has been undertaken. The discovery of compounds that are potent FPT inhibitors in the nanomolar range has been achieved. These compounds are nonpeptidic and do not contain sulfhydryl groups. They selectively inhibit farnesyl protein transferase (FPT) and not geranylgeranyl protein transferase-1 (GGPT-1). They also inhibit H-Ras processing in Cos monkey kidney cells.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301041
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