Title of article
Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers Original Research Article
Author/Authors
Guofeng Jia، نويسنده , , J. William Lown، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
11
From page
1607
To page
1617
Abstract
Three types of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers were designed, synthesized and evaluated in vitro by NCI against nine types of cancer cells. Biological results showed that the antitumor activities of these seco-CBI dimers were strongly related to the position and length of the linker and generally with potency increasing in the order of C7–C7 dimers (22i–iv)
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2000
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301088
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