Title of article
Synthesis of [11C]RPR-72840A and its evaluation as a radioligand for the serotonin reuptake site in positron emission tomography Original Research Article
Author/Authors
Dirk Roeda، نويسنده , , Bertrand Tavitian، نويسنده , , Christine Coulon، نويسنده , , Frédérique David، نويسنده , , Frédéric Dollé، نويسنده , , Chantal Fuseau، نويسنده , , Antoinette Jobert، نويسنده , , Christian Crouzel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
7
From page
397
To page
403
Abstract
RPR-72840A, an inhibitor of serotonin reuptake, was labelled with carbon-11. The synthesis of the nonradioactive precursor, which exhibited some unexpected chemistry, and its reaction with [11C]phosgene affording [11C]RPR-72840A are described. Biodistribution studies in rats and PET studies in baboons were conducted to evaluate [11C]RPR-72840A as a tracer for PET imaging of the serotonin reuptake system.
Keywords
serotonin reuptake
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301102
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