Title of article
Synthesis of indolylalkoxyiminoalkylcarboxylates as leukotriene biosynthesis inhibitors Original Research Article
Author/Authors
Teodozyj Kolasa، نويسنده , , Pramila Bhatia، نويسنده , , Clint D.W. Brooks، نويسنده , , Keren I. Hulkower، نويسنده , , Jennifer B. Bouska، نويسنده , , Richard R. Harris، نويسنده , , Randy L. Bell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
8
From page
507
To page
514
Abstract
A series of substituted indolylalkoxyiminoalkylcarboxylates were found to be potent leukotriene biosynthesis inhibitors. The structure-activity relationships were investigated. Representative potent inhibitors identified were the quinolyl 3a (A-86885) and pyridyl 3b (A-86886) congeners with in vitro IC50s of 21 and 9 nM and in vivo leukotriene inhibition in the rat with oral ED50s of 0.9 and 1.7 mg/kg, respectively.
Keywords
carbonic anhydrase inhibitors , carbonic anhydrase isozymes
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301129
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