Title of article
Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems Original Research Article
Author/Authors
Hideaki Imamura، نويسنده , , Norikazu Ohtake، نويسنده , , Aya Shimizu، نويسنده , , Hiroki Sato، نويسنده , , Yuichi Sugimoto، نويسنده , , Shunji Sakuraba، نويسنده , , Rie Nagano، نويسنده , , Masato Nakano، نويسنده , , Shinnosuke Abe، نويسنده , , Chihiro Suzuki-Sato، نويسنده , , Ikuko Nishimura، نويسنده , , Hisaki Kojima، نويسنده , , Yoshimi Tsuchiya، نويسنده , , Koji Yamada، نويسنده , , Terutaka Hashizume، نويسنده , , Hajime Morishima، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
14
From page
1969
To page
1982
Abstract
Novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems were designed and synthesized to provide J-111,347 () as the first example of an exceptionally broad-spectrum antibiotic, showing activity against methicillin-resistant Staphyloccocus aureus (MRSA) as well as Pseudomonas aeruginosa. Further derivation of afforded J-111,225 (), J-114,870 (), and J-114,871 (), which showed improved safety profiles and retained broad-spectrum antibacterial activities.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2000
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301139
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