Title of article
Synthesis and antimicrobial activity of squalamine analogue Original Research Article
Author/Authors
Hong-Seok Kim، نويسنده , , Bo-Seung Choi، نويسنده , , Kyung-Chan Kwon، نويسنده , , Sang-Ok Lee، نويسنده , , Hyun Jung Kwak، نويسنده , , Cheol Hae Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
7
From page
2059
To page
2065
Abstract
Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3β-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2000
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301156
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