Title of article :
Evaluation of a Series of Anticonvulsant 1,2,3,4-Tetrahydroisoquinolinyl-benzamides Original Research Article
Author/Authors :
Wai N. Chan، نويسنده , , Michael S. Hadley، نويسنده , , John D. Harling، نويسنده , , Hugh J. Herdon، نويسنده , , Barry S. Orlek، نويسنده , , Graham J. Riley، نويسنده , , Rachel E.A. Stead، نويسنده , , Tania O. Stean، نويسنده , , Mervyn Thompson، نويسنده , , Neil Upton، نويسنده , , Robert W. Ward، نويسنده ,
Abstract :
SAR studies around a series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides, identified by high-throughput screening at the novel SB-204269 binding site, have provided compounds such as 13, 29–33 with high affinity and excellent anticonvulsant activity in animal models.
