Author/Authors :
Bruce E. Eaton، نويسنده , , Larry Gold، نويسنده , , Brian J. Hicke، نويسنده , , Neboj?a Janjié، نويسنده , , Fiona M. Jucker، نويسنده , , David P. Sebesta، نويسنده , , Theodore M. Tarasow، نويسنده , , Michael C. Willis، نويسنده , , Dominic A. Zichi، نويسنده ,
Abstract :
In vitro selection techniques provide a means of isolating nucleic acid ligands for binding to particular protein targets. Although most aptamers have quite high affinities for their target proteins, it has been shown that post-SELEX modification can result in further enhancement of binding affinity, as well as other desired properties. This has led to the current development of a more systematic approach to aptamer optimization using a combinatorial screening methodology.
