Title of article
New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase Original Research Article
Author/Authors
Béatrice Bonnet، نويسنده , , David Soullez، نويسنده , , Elisabeth Davioud-Charvet، نويسنده , , Valérie Landry، نويسنده , , Dragos Horvath، نويسنده , , Christian Sergheraert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
8
From page
1249
To page
1256
Abstract
Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (Ki = 0.4 μM) is the most potent TR inhibitor described so far.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301228
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