Title of article
HL 752: A potent and long-acting antispasmodic agent Original Research Article
Author/Authors
Swati Bal-Tembe، نويسنده , , Dilip N. Bhedi، نويسنده , , Anil K. Mishra، نويسنده , , Ramanujam Rajagopalan، نويسنده , , Anil V. Ghate، نويسنده , , Palakodety Subbarayan، نويسنده , , Narayan S. Punekar، نويسنده , , Anjali V. Kulkarni، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
7
From page
1381
To page
1387
Abstract
Ester analogues of methyl-2-(4-(2-piperidinoethoxy)benzoyl)-benzoate hydrochloride (pitofenone) (2) were prepared with an aim to find a more potent and metabolically stable antispasmodic compound. The compounds were evaluated for their in vitro and in vivo antispasmodic activity, and stability to in vitro enzymatic hydrolysis. Of the compounds synthesised, HL 752 (21) showed the most potent and long-lasting antispasmodic activity and was selected as the candidate for clinical development.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301265
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