Author/Authors :
Akira Uchimura، نويسنده , , Toshiyuki Shimizu، نويسنده , , Miiko Nakajima، نويسنده , , Hitomi Ueno، نويسنده , , Kazuhiro Motoki، نويسنده , , Hideaki Fukushima، نويسنده , , Takenori Natori، نويسنده , , Yasuhiko Koezuka، نويسنده ,
Abstract :
We examined the effects of 2″- or 3″-monoglycosylated α-galactosylceramides (α-GalCers) and 2″,3″-diglycosylated α-GalCers on allogeneic MLR and the proliferation of murine spleen cells. It was found that their ceramide portions greatly affect their immunostimulatory activities, and that the 3″-hydroxyl group plays a more important role in the immunostimulatory effects of α-GalCer derivatives than the 2″-hydroxyl group.
