Title of article :
2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE2 antagonist Original Research Article
Author/Authors :
E. Ann Hallinan، نويسنده , , Timothy J. Hagen، نويسنده , , Sofya Tsymbalov، نويسنده , , Awilda Stapelfeld، نويسنده , , Michael A. Savage، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride (1, SC-51089) is a functional PGE2 antagonist selective for the EP1 receptor subtype with antinociceptive activity.1,2 Analogues of SC-51089, in which the diacylhydrazine moiety has been replaced with 2,4-disubstituted-oxazoles and-thiazoles, are described.
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
