Title of article
Synthesis and bioactivity of 2,4-diacyl analogues of paclitaxel Original Research Article
Author/Authors
Mahendra D. Chordia، نويسنده , , Haiqing Yuan، نويسنده , , Prakash G. Jagtap، نويسنده , , John F. Kadow، نويسنده , , Byron H. Long، نويسنده , , Craig R Fairchild، نويسنده , , Kathy A Johnston، نويسنده , , David G.I Kingston، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
8
From page
171
To page
178
Abstract
The 2,4-diacyl paclitaxel analogues 8a–8r were prepared from paclitaxel by acylation of 4-deacetyl-2-debenzoylpaclitaxel 1,2-carbonate () followed either by hydrolysis of the carbonate and acylation or by direct treatment of the carbonate with an aryllithium. Some of the resulting derivatives showed significantly improved tubulin assembly activity and cytotoxicity as compared with paclitaxel; in some cases this improvement was especially significant for paclitaxel-resistant cell lines.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2001
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301324
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