Title of article :
Synthesis and evaluation of A-Ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D3 (OCT) Original Research Article
Author/Authors :
Susumi Hatakeyama، نويسنده , , Toshio Okano، نويسنده , , Junji Maeyama، نويسنده , , Tomoyuki Esumi، نويسنده , , Hiroko Hiyamizu، نويسنده , , Yoshiharu Iwabuchi، نويسنده , , Kimie Nakagawa، نويسنده , , Keiichi Ozono، نويسنده , , Akira Kawase، نويسنده , , Noboru Kubodera، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
A-ring diastereomers of 1α,25-dihydroxy-22-oxavitamin D3 (OCT) (2), 3-epi-1α,25-dihydroxy-22-oxavitamin D3 (3-epiOCT) (3) and 1,3-diepi-1α,25-dihydroxy-22-oxavitamin D3 (1,3-diepiOCT) (4) were synthesized by the convergent method. In vitro binding affinity for rat vitamin D binding protein and calf-thymus vitamin D receptor, differentiation-inducing activity on HL-60 cells, and transcriptional activity of 3-epiOCT (3) and 1,3-diepiOCT (4) were evaluated in comparison with OCT (2), 1-epi-1α,25-dihydroxy-22-oxavitamin D3 (1-epiOCT) (5) and 1α,25-dihydroxyvitamin D3 (1).
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
