Title of article :
Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors Original Research Article
Author/Authors :
Graham A. Showell، نويسنده , , Frances Emms، نويسنده , , Rosemarie Marwood، نويسنده , , Desmond OʹConnor، نويسنده , , Smita Patel، نويسنده , , Paul D. Leeson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
The synthesis of a series of 2,4-disubstituted morpholines is described and their affinities at human dopamine receptors reported. The orally bioavailable 7-azaindole compound 11 has nanomolar affinity at the hD4 receptor with >1000-fold selectivity over the hD2 receptor.
Keywords :
Ligands , Dopamine , Receptors , Morpholine , psychosis
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
