Title of article
Binding of 2,4-disubstituted morpholines at human D4 dopamine receptors Original Research Article
Author/Authors
Graham A. Showell، نويسنده , , Frances Emms، نويسنده , , Rosemarie Marwood، نويسنده , , Desmond OʹConnor، نويسنده , , Smita Patel، نويسنده , , Paul D. Leeson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
8
From page
1
To page
8
Abstract
The synthesis of a series of 2,4-disubstituted morpholines is described and their affinities at human dopamine receptors reported. The orally bioavailable 7-azaindole compound 11 has nanomolar affinity at the hD4 receptor with >1000-fold selectivity over the hD2 receptor.
Keywords
Ligands , Dopamine , Receptors , Morpholine , psychosis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301428
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