Title of article
Synthesis and antimuscarinic activity of some ether- and thioether-bearing 1,3-dioxolanes and related sulfoxides and sulfones Original Research Article
Author/Authors
Luca Malmusi، نويسنده , , Silvia Franchini، نويسنده , , Adele Mucci، نويسنده , , Luisa Schenetti، نويسنده , , Ugo Gulini، نويسنده , , Gabriella Marucci، نويسنده , , Livio Brasili، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
8
From page
825
To page
832
Abstract
A series of 1,3-dioxolane-based ligands, bearing ether, thioether and related sulfoxide and sulfone functionalities, were synthesised and tested as potential muscarinic antagonists. The compounds display moderate to low affinity for the three receptor subtypes M1–M3, with some of them showing a significant selectivity for the M1–M3 over the M2 subtype.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301572
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