Author/Authors :
Hanumantharao G. Raj، نويسنده , , Virinder S. Parmar، نويسنده , , Subhash C. Jain، نويسنده , , Sanjay Goel، نويسنده , , Poonam Himanshu، نويسنده , , Sanjay Malhotra، نويسنده , , Amarjit Singh، نويسنده , , Carl E Olsen، نويسنده , , Jesper Wengel، نويسنده ,
Abstract :
Twenty-three 4-methylcoumarins bearing different functionalities have been examined for the first time for their effect on NADPH-catalysed liver-microsomal lipid peroxidation with a view to establish structure–activity relationship. Dihydroxy- and diacetoxy-4-methylcoumarins produced dramatic inhibition of lipid peroxidation. 7,8-Diacetoxy-4-methylcoumarin and 7,8-dihydroxy-4-methylcoumarin were found to possess superb antioxidant and radical scavenging activities.