Syntheses and Cytotoxicities of Four Stereoisomers of Muricatacin from d-Glucose Original Research Article

Four stereoisomers of muricatacin 1a–d were prepared by the reaction of corresponding aldehydes 4a–d, which in turn were prepared from d-glucose, with the anion of triethylphosphonoacetate followed by reduction and cyclization under acidic conditions. Cytotoxicities of four stereoisomers were tested against in vitro A-549 cell line as well as MCF-7 cell line. Stereochemistry at C4 and C5 position of muricatacin did not affect the cytotoxicities significantly.