Potentiation of BCNU Cytotoxicity by Molecules Targeting Abasic Lesions in DNA Original Research Article

We describe the synthesis, DNA binding measurements and pharmacological properties of a series of new heterodimeric molecules, in which a 2,6-diaminopurine is linked to a 9-aminoacridine chromophore. The linking chain contains a central N,N′-disubstituted guanidine, connected to the two chromophores by polymethylenic units of variable length.