Title of article
Potentiation of BCNU Cytotoxicity by Molecules Targeting Abasic Lesions in DNA Original Research Article
Author/Authors
Karine Alarcon، نويسنده , , Martine Demeunynck، نويسنده , , Jean Lhomme، نويسنده , , Danièle Carrez، نويسنده , , Alain Croisy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
10
From page
1901
To page
1910
Abstract
We describe the synthesis, DNA binding measurements and pharmacological properties of a series of new heterodimeric molecules, in which a 2,6-diaminopurine is linked to a 9-aminoacridine chromophore. The linking chain contains a central N,N′-disubstituted guanidine, connected to the two chromophores by polymethylenic units of variable length.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2001
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301674
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