Synthesis and biological evaluation of methoxyphenyl porphyrin derivatives as potential photodynamic agents Original Research Article

A new meso-2,4,6-trimethoxyphenyl porphyrin covalently linked to a 2′,6′-dinitro-4′-trifluoromethylphenyl group by an amine bond 5 and its metal complex with Cd(II) 6 was prepared. The photodynamic activities of 5 and 6 were evaluated in vitro on Hep-2 cells. A considerable increase in the photocytotoxic effect was found for 6, which has higher singlet molecular oxygen, O2(1Δg), production.