Title of article
Structure–activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor Original Research Article
Author/Authors
Hélène Juteau، نويسنده , , Yves Gareau، نويسنده , , Marc Labelle، نويسنده , , Claudio F. Sturino، نويسنده , , Nicole Sawyer، نويسنده , , Nathalie Tremblay، نويسنده , , Sonia Lamontagne، نويسنده , , Marie-Claude Carrière، نويسنده , , Danielle Denis، نويسنده , , Kathleen M. Metters، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
8
From page
1977
To page
1984
Abstract
Potent and selective antagonists of the human EP3 receptor have been identified. The structure–activity relationship of the chemical series was conducted and we found several analogues displaying sub-nanomolar Ki values at the EP3 receptor and micromolar activities at the EP1, EP2 and EP4 receptors. The effect of added human serum albumin (HSA) on the binding affinity at the EP3 receptor was also investigated.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2001
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301686
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