Synthesis and QSAR Studies of 4-Substituted phenyl-2,6-dimethyl-3, 5-bis-N-(substituted phenyl)carbamoyl-1,4-dihydropyridines as potential antitubercular agents Original Research Article

Synthesis and QSAR studies of the title compounds have resulted in the identification of structural and physicochemical parameters (MR, σo, σm, σp) contributing to antitubercular activity. Among these, carbamoyl phenyl ring substituted at 3 and 4 position with NO2 group or 2 position with Cl or OCH3 group shows >90% inhibition against H37Rν comparable to other substituted phenyls.