Title of article
Total synthesis of 25-Hydroxy-16,23E-diene Vitamin D3 and 1α,25-Dihydroxy-16,23E-diene Vitamin D3: separation of genomic and nongenomic vitamin D Activities Original Research Article
Author/Authors
Marek M. Kabat، نويسنده , , Walter Burger، نويسنده , , Sandra Guggino، نويسنده , , Bernard Hennessy، نويسنده , , Jerome A. Iacobelli، نويسنده , , Kazuhiro Takeuchi، نويسنده , , Milan R. Uskokovic، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
9
From page
2051
To page
2059
Abstract
Separation of genomic and nongenomic vitamin D activities was achieved by structural modification of 1,25-dihydroxy vitamin D3 by introduction of 16 and 23E double bonds. The modified compound 3, lacking a 1α-hydroxy group, exhibits only nongenomic activity. Its 1α-hydroxy relative 4 expresses fully both genomic and nongenomic activities. A total synthesis of analogues 3 and 4 is described.
Keywords
Vitamin D3 analogues , genomic effect , calcium channel , nongenomic effect , transcriptional effect
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301806
Link To Document