Title of article
Hydroxyacyl derivatives of forskolin—their positive inotropic activity Original Research Article
Author/Authors
Sanjay Arora, Bansi Lal، نويسنده , , Ashok Kumar Gangopadhyay، نويسنده , , Ramanujam Rajagopalan، نويسنده , , Anil Vasantrao Ghate، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
13
From page
2061
To page
2073
Abstract
Using appropriate protection and deprotection sequence novel hydroxyacyl chains of the type CO(CH2)nOH are synthesized and are utilized to develop new analogues of forskolin. Several compounds showed good positive inotropic activity. Compound 12 is almost 10 times more active than forskolin (EC50=0.002 μg/ml).].
Keywords
Forskolin , positive inotropic activity , 2-hydroxyacetyl
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301807
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