QSAR Studies on acylated histamine derivatives Original Research Article

H3-receptor antagonists activity in terms of −log Ki for a series of acylated histamine derivatives was modeled using topological indices, namely negentropy (N), molecular redundancy (MRI), and valence connectivity index (mxv) indices. Excellent results were obtained in multiple regression analysis upon the introduction of a dummy parameter (indicator parameter). Consistant increase in R2A value indicated that inspite of observed collinearity the proposed models are significant.