Author/Authors :
Yoshiyuki Ono، نويسنده , , Akira Kawase، نويسنده , , Hiroyoshi Watanabe، نويسنده , , Ayako Shiraishi، نويسنده , , Satoshi Takeda، نويسنده , , Yoshinobu Higuchi، نويسنده , , Shinji Miyano
Katsuhiko Sato
Kenji Numata
، نويسنده , , Tsuyoshi Yamauchi، نويسنده , , Tetsuhiro Mikami، نويسنده , , Masahiro Kato، نويسنده , , Naoko Tsugawa، نويسنده , , Toshio Okano، نويسنده , , Noboru Kubodera، نويسنده ,
Abstract :
Analogues related to 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity.
