Author/Authors :
Yasunori Aoyama، نويسنده , , Masaaki Uenaka، نويسنده , , Makoto Kii، نويسنده , , Mamoru Tanaka، نويسنده , , Toshiro Konoike*، نويسنده , , Yoko Hayasaki-Kajiwara، نويسنده , , Noriyuki Naya، نويسنده , , Masatoshi Nakajima، نويسنده ,
Abstract :
3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure–activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, which exhibited 3.1 nM inhibition of human chymase and enhancement of stability in human plasma (t1/2 6 h).
