Title of article
Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors Original Research Article
Author/Authors
Yasunori Aoyama، نويسنده , , Masaaki Uenaka، نويسنده , , Makoto Kii، نويسنده , , Mamoru Tanaka، نويسنده , , Toshiro Konoike*، نويسنده , , Yoko Hayasaki-Kajiwara، نويسنده , , Noriyuki Naya، نويسنده , , Masatoshi Nakajima، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
11
From page
3065
To page
3075
Abstract
3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure–activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, which exhibited 3.1 nM inhibition of human chymase and enhancement of stability in human plasma (t1/2 6 h).
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2001
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301880
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