Multiple reactive immunization towards the hydrolysis of organophosphorus nerve agents: hapten design and synthesis Original Research Article

We designed and synthesized a series of haptens to elicit catalytic antibodies with phosphatase activity against nerve agents. The design is based on the novel concept of multiple reactive immunization which aims to afford two or more catalytic residues within the antibodyʹs binding cleft. The haptens showed the desired reactivity in vitro and were submitted for immunization.