QSAR Studies on some antimalarial sulfonamides Original Research Article

Antimalarial activity of a series of sulfonamide derivatives (2,4-diamino-6-quinazoline sulfonamides) was modeled topologically using Wiener (W)-, and Szeged (Sz)-indices. The regression analysis of the data has shown that better results are obtained in multiparametric regressions upon introduction of indicator parameters. Predicting ability of the models was tested by r2cv values. It was observed that models based on W index gave slightly better results than those in which Sz is involved.