Title of article
N,N-Disubstituted Aminomethyl Benzofuran Derivatives: Synthesis and Preliminary Binding Evaluation Original Research Article
Author/Authors
Sophie Boyé، نويسنده , , Bruno Pfeiffer، نويسنده , , Pierre Renard، نويسنده , , Marie-Claire Rettori، نويسنده , , Gérald Guillaumet، نويسنده , , Marie-Claude Viaud، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
7
From page
335
To page
341
Abstract
A series of new N-substituted 2,3-dihydro-2-aminomethyl-2H-1-benzofuran derivatives was prepared and evaluated for affinity at 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3, D2, and D3 receptors. Compound 9, 8-[4-[N-propyl-N-(7-hydroxy-2,3-dihydro-2H-1-benzofuran-2-yl)methyl]aminobutyl]-8-azaspiro[4,5]decane-7,9-dione, bound at 5-HT1A sites with nanomolar affinity (IC50=1.5 nM) and high selectivity over 5-HT2A, 5-HT2C, 5-HT3, D2, and D3 receptors. ©
Keywords
Ring contraction , serotoninergic and dopaminergic receptor binding , 2 , 3-Dihydro-2-aminomethyl-2H-1-benzofurans
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301938
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