Title of article :
Synthesis and pharmacological evaluation of novel cis-3,4-Diaryl-hydroxychromanes as high affinity partial agonists for the estrogen receptor Original Research Article
Author/Authors :
The syntheses and in vitro pharmacological evaluation of a number of cis-3، نويسنده , , 4-diaryl-hydroxy-chromanes are reported، نويسنده , , along with the results of a thorough in vivo profiling of the tissue-selective estrogen partial-agonist NNC 45-0781 [3، نويسنده , , 3S.T. Somasundaram، نويسنده , , 4R)-7-hydroxy-3-phenyl-4-(4-(2-pyrrolidinoethoxy)phenyl)chromane]. These studies showed that NNC 45-0781 is a very promising candidate for the prevention of post-menopausal osteoporosis، نويسنده , , and the treatment of other health issues related to the loss of endogenous estrogen production.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Paul S. Bury, Lise B. Christiansen, Poul Jacobsen, Anker S. Jørgensen, Anders Kanstrup, Lars Nærum, Steven Bain, Christian Fledelius, Birgitte Gissel, Birgit S. Hansen, Niels Korsgaard, Susan M. Thorpe, Karsten Wassermann
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
