Title of article
Synthesis and cytotoxic activity of tetracenomycin d and of saintopin analogues Original Research Article
Author/Authors
Philippe Martin، نويسنده , , Stéphane Rodier، نويسنده , , Martine Mondon، نويسنده , , Brigitte Renoux، نويسنده , , Bruno Pfeiffer، نويسنده , , Pierre Renard، نويسنده , , Alain Pierré، نويسنده , , Jean-Pierre Gesson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
8
From page
253
To page
260
Abstract
Regiospecific synthesis of title compounds is based either on cycloaddition of ketene acetals derived from Hagemannʹs ester or of homophthalic anhydrides. Thus, tetracenomycin D and 3,8-di-O-methyl saintopin have been prepared in few steps. New derivatives of 10-deoxysaintopin have been also obtained. Evaluation of their cytotoxicity against L1210 leukemia cells are reported.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301960
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