Title of article :
A new solid-phase synthesis of oligonucleotides 3′-conjugated with peptides Original Research Article
Author/Authors :
L De Napoli، نويسنده , , A Messere، نويسنده , , D Montesarchio، نويسنده , , G Piccialli، نويسنده , , E Benedetti، نويسنده , , E Bucci، نويسنده , , F Rossi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
A convenient ‘on line’ solid-phase synthesis of oligonucleotides conjugated at the 3′-end with peptides by means of a polymeric support linking the first nucleoside via the base has been developed. A 17-mer designed for antisense experiments against HIV-1, linking at the 3′-terminus the tripeptide Gly-Gly-His, was prepared in good yields and characterized by MALDI-TOF mass spectrometry. ©
Keywords :
Nucleic acids , Peptides , HIV , Solid-phase synthesis
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
