Title of article
A new solid-phase synthesis of oligonucleotides 3′-conjugated with peptides Original Research Article
Author/Authors
L De Napoli، نويسنده , , A Messere، نويسنده , , D Montesarchio، نويسنده , , G Piccialli، نويسنده , , E Benedetti، نويسنده , , E Bucci، نويسنده , , F Rossi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
395
To page
400
Abstract
A convenient ‘on line’ solid-phase synthesis of oligonucleotides conjugated at the 3′-end with peptides by means of a polymeric support linking the first nucleoside via the base has been developed. A 17-mer designed for antisense experiments against HIV-1, linking at the 3′-terminus the tripeptide Gly-Gly-His, was prepared in good yields and characterized by MALDI-TOF mass spectrometry. ©
Keywords
Nucleic acids , Peptides , HIV , Solid-phase synthesis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301971
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